Which screening tests for mutations in a compound?

Which screening tests for mutations in a compound?

• A. Cytotoxicity
• B. Neurotoxicity
• C. Genotoxicity
• D. Immunotoxicity

Answer: (C)

Genotoxicity is the property of a chemical that damages DNA or causes genetic mutations. Screening tests for mutations in a compound aim to detect mutagenic potential to prevent heritable changes and cancer risk. Classic examples include the Ames test, which detects mutagenicity in bacteria, and assays like the micronucleus or comet assay that reveal DNA damage in mammalian cells. In contrast, cytotoxicity measures overall cell viability, neurotoxicity assesses effects on the nervous system, and immunotoxicity looks at immune system impact. Because the focus is on mutations at the genetic level, genotoxicity is the appropriate screening category.

Genotoxicity is the property of a chemical that damages DNA or causes genetic mutations. Screening tests for mutations in a compound aim to detect mutagenic potential to prevent heritable changes and cancer risk. Classic examples include the Ames test, which detects mutagenicity in bacteria, and assays like the micronucleus or comet assay that reveal DNA damage in mammalian cells. In contrast, cytotoxicity measures overall cell viability, neurotoxicity assesses effects on the nervous system, and immunotoxicity looks at immune system impact. Because the focus is on mutations at the genetic level, genotoxicity is the appropriate screening category.